A none issue with http2 and the imminent wide adoption of http3.
Also, core is optimized to handle db queries from multiple plugins simultaneously without impacting performance. Redis is still recommended for minimizing db queries. As I stated in other posts, PHP is CPU-bound so shoot for 2.5Ghz+ when clustering and preferably 3GHz+/16GB to 32GB RAM for AIO single VM usage.
I have 50+ enabled currently.