Is it possible to change the comma by dash in search url example when I search trt I get an url /search/q,trt I want to change that so my url return /search/q-trt
or if I select a category in search result page I get a link /search/q,trt/category,photography so I want to change that to /search/q-trt/category-photography
is there a way to change that on the php files . I even deactivate friendly urls and tried to build my htaccess but seems that not working.
Is it possible to deactive friendly url for search

No you cannot change this.

I did disable friendly URLS but my htaccess not working

Htaccess is just file generated by osclass (but can be also manually created).
Disabled friendly urls will ignore htaccess

is it possible to disable friendly url and without ignoring htaccess

I think you do not understand much how it works.
Disabling friendly urls only remove not necessary code from htaccess, but this file can be there with different rules