You need to place the lines below into config.php file located at the root of your installation.
This way you will see what is the reason of your error 500 sicne you will see the logs.
define(OSC_DEBUG, true);
define(OSC_DEBUG_LOG, true);
define(OSC_DEBUG_DB, true);
I had the same error and i solved it this way: ( this does not mean you have the same issue but to know it you need see the error log )
Settings --> Mail Server - >Use POP before SMTP
uncheck this and tell me if it works now.